ADVANCED THERANOSTIC APPROACH IN CANCER COMBINING PHOTODYNAMIC THERAPY AND NPS
Real time stages of the project
Stage 1
“Theranostics” is a global medical concept combining imaging and therapy to optimize personalized medical plans […]
Stage II
Research focused on photosensitizers’ toxicity / efficacy profile continued in this stage with „in vitro” studies on cytotoxicity and incorporation of porphyrinic compounds P.1.2 and P.4.2 […]
Stage III
At this stage of the project, there have been defined optimized procedures for „in vitro”, preclinical investigations of nano-systems and photosensitizers […]
Stage IV
The „in vitro” models proved the efficacy of red clover and fenugreek extracts as cellular protectors for normal cells from tumours niche (fibroblasts and keratinocytes) through […]
Conclusions
Short Abstract
Considering the compelling need for personalized and targeted therapy in cancer, the main objective is to design, produce and characterize new theranostic agents (polymer-coated nanoparticles with porphyrins) for photodynamic therapy. Pharmacological modulation of the endogenous antioxidant system will be used as co-therapy. Applied research for product development in preclinical setting will be complemented by advanced mechanistic studies. The project meets the M-ERA.NET topic “Tailoring of bioactive material surfaces for health applications”.